Pro and Contra: Provocation Tests in Drug Hypersensitivity

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Pro and Contra: Provocation Tests in Drug Hypersensitivity

Drug provocation test (DPT) is the controlled administration of a drug to diagnose immune- or non-immune-mediated drug hypersensitivity and the last step for accurate recognition of drug hypersensitivity reactions when the previous diagnostic evaluations are negative or unavailable. A DPT is performed only if other conventional tests fail to yield conclusive results. In each clinical presentati...

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Provocation tests in drug allergy

Almost two-thirds of patients who visit a doctor for a reaction that is diagnosed as a ‘drug allergy’ (DA) are not allergic. This false claims of drug allergy leads to unnecessary avoidance of fi rst choice drugs, exposes the patient to less effective and potentially more toxic drugs, increases healthcare costs, and contributes to the development of antibiotic resistance. Therefore, a drug alle...

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Fixed drug eruption and intradermal provocation tests.

OBJECTIVE To determine the role of Intradermal Provocation (IDP) tests in Fixed Drug Eruption (FDE). STUDY DESIGN Quasi-experimental study. PLACE AND DURATION OF STUDY Dermatology Unit, Shaikh Zayed Hospital, Lahore, from August 2004 to July 2006. METHODOLOGY The tests were performed in 96 patients in two stages. At stage I, suspected drugs were given intradermally. Changes at injection s...

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Drug provocation tests in children: Indications and interpretation.

Drug provocation tests in children are always a problematic task. In the present article the most important aspects of this technique are reviewed, including the differences between children and adults; the main mechanisms involved in drug reaction; how to perform the different tests; and when they are indicated.

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ژورنال

عنوان ژورنال: International Journal of Molecular Sciences

سال: 2017

ISSN: 1422-0067

DOI: 10.3390/ijms18071437